Demonstration of fundamental mode only propagation in highly multimode fibre for high power EDFAs

The use of short lengths of large core phosphate glass fibre, doped with high concentrations of Er or Er:Yb represents an attractive route to achieving high power erbium doped fibre amplifiers (EDFAs) and lasers (EDFLs). With the aim of investigating the potential of achieving diffraction limited output from such large core fibres, we present experimental results of fundamental mode propagation through a 20 cm length of passive 300 micrometer core multimode fibre when the input is a well-aligned Gaussian beam. Through careful control of fibre geometry, input beam parameters and alignment, we measured an output M squared of 1.1 + - 0.05. The fibre had a numerical aperture of 0.389, implying a V number of 236.8. To our knowledge, this is the largest core fibre through which diffraction limited fundamental mode propagation has been demonstrated. Although the results presented here relate to undoped fibre, they do provide the practical basis for a new generation of EDFAs and EDFLs.Comment: 5 figure

A longitudinal investigation of repressive coping and ageing

This is an Accepted Manuscript of an article published by Taylor & Francis in Aging & Mental Health on October 2016, available online: http://www.tandfonline.com/doi/full/10.1080/13607863.2015.1060941.Two studies investigated the possibility that repressive coping is more prevalent in older adults and that this represents a developmental progression rather than a cohort effect. Study 1 examined repressive coping and mental health cross-sectionally in young and old adults. Study 2 examined whether there was a developmental progression of repressive coping prevalence rates in a longitudinal sample of older adults.Peer reviewedFinal Accepted Versio

Temporal, spatial, and structural patterns of adult trembling aspen and white spruce mortality in Quebec's boreal forest

Temporal, spatial, and structural patterns of adult trembling aspen (Populus tremuloides Michx.) and white spruce (Picea glauca (Moench) Voss) mortality were studied in intact 150-year-old stands in the southwestern boreal forest of Quebec. For both species, mortality decreases (number of dead trees/total number of trees) with distance from the lake edge until 100-150 m, from which point it slightly increases. Strong peaks in mortality were found for 40- to 60-year-old aspen mainly between 1974 and 1992. Such mortality in relatively young aspen is likely related to competition for light from the dominant canopy trees. Also, the recruitment of this young aspen cohort is presumably the result of a stand breakup that occurred when the initial aspen-dominated stand was between 90 and 110 years old. For spruce, strong peaks in mortality were found in 110- to 150-year-old trees and they occurred mainly after 1980. No clear explanation could be found for these peaks, but we suggest that they may be related to senescence or weakening of the trees following the last spruce budworm outbreak. Suppressed and codominant aspen had a much higher mortality ratio than spruce in the same height class, while more surprisingly, no difference in mortality rate was found between dominant trees of the two species. Most spruce trees were found as standing dead, which leads us to reject the hypothesis that windthrow is an important cause of mortality for spruce in our forests

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus

A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10-20), ER-negative BC (P=1.1 × 10-13), BRCA1-associated BC (P=7.7 × 10-16) and triple negative BC (P-diff=2 × 10-5). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10-3) and ABHD8 (P<2 × 10-3). Chromosome conformation capture identifies interactions between four candidate SNPs and ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 promoter. Targeted deletion of a region containing risk SNP rs56069439 in a putative enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an ANKLE1 3′-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk

The genesis of gold mineralisation hosted by orogenic belts: A lead isotope investigation of Irish gold deposits

Lead isotope analyses have been performed on 109 gold and 23 sulphide samples from 34 Irish gold occurrences, including 27 placers, and used to shed light on the sources of mineralising fluids and metals associated with gold mineralisation hosted by orogenic belts. The Pb isotope ratios of lode and placer gold range from 206Pb/204Pb=17.287-18.679, 207Pb/204Pb=15.382-15.661, and 208Pb/204Pb=37.517-38.635, consistent with the Pb isotopic data on previously reported Irish sulphide mineralisation. There is no evidence that gold mineralisation is associated with distinctive source regions, and it appears to have been derived from similar sources to those responsible for the widespread sulphide mineralisation in Ireland. It is inferred that the principal controls on the Au mineralisation are structural and not related to the distribution of Au in their source rocks. The range of Pb isotope ratios favours the interaction of multiple source reservoirs predominantly during the Caledonian Orogeny (c. 475-380Ma). Underlying basement was the primary control on two key sources of Pb. Gold occurrences located to the south-east of the Iapetus Suture are characterised by Pb compositions that derive predominantly from the Late Proterozoic crustal basement or overlying Lower Palaeozoic sediments, whilst those located north-west of the Iapetus Suture are characterised by less radiogenic Pb signatures derived predominantly from Late Proterozoic or older crustal basement. A third source, relatively enriched in radiogenic Pb, also played a role in the formation of a number of Irish gold occurrences, and may have been associated with syn- to post-orogenic intrusives. Magmatic processes may therefore have played an important role in the formation of some orogenic gold occurrences

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

Igneous rocks in the Fish Creek Mountains and environs, Battle Mountain area, north-central Nevada: A microcosm of Cenozoic igneous activity in the northern Great Basin, Basin and Range Province, USA

The Great Basin of the western United States, the northern component of the Basin and Range Province, is a region of Cenozoic lithospheric extension with multiple periods and types of igneous activity. The composition and volume of Cenozoic magmas reflect a complex interaction between mantle-derived magmas and highly diverse crust, where both mantle sources and magmatic processes were modulated by tectonic environment. The Fish Creek Mountains in north-central Nevada underwent multiple igneous events ranging from ca. 40 Ma to 1 Ma that span all of the complex Cenozoic tectono-magmatic episodes of the Great Basin. The Fish Creek Mountains, therefore, is an ideal location to evaluate the different sources and processes involved in magma generation. Many plutons were emplaced in the region between about 40 and 38 Ma, several of which host base and precious metal deposits. Between 36 and 33 Ma, lava fields and calderas of the 37–19 Ma Ignimbrite Flare-up were emplaced. Both these and the preceding plutons resulted from southwestward rollback of the Farallon plate beneath North America during by far the most voluminous phase of Cenozoic magmatism. The lavas range from rare basalt and basaltic andesite to andesite, dacite, and rhyolite, have continental arc-like incompatible element patterns, and high initial 87 Sr/ 86 Sr and low εNd that require a metasomatized lithospheric mantle sour

SHARP – VI. Evidence for CO (1–0) molecular gas extended on kpc-scales in AGN star-forming galaxies at high redshift

We present a study of the stellar host galaxy, CO (1–0) molecular gas distribution and AGN emission on 50–500 pc-scales of the gravitationally lensed dust-obscured AGN MG J0751+2716 and JVAS B1938+666 at redshifts 3.200 and 2.059, respectively. By correcting for the lensing distortion using a grid-based lens modelling technique, we spatially locate the different emitting regions in the source plane for the first time. Both AGN host galaxies have 300–500 pc-scale size and surface brightness consistent with a bulge/pseudo-bulge, and 2 kpc-scale AGN radio jets that are embedded in extended molecular gas reservoirs that are 5–20 kpc in size. The CO (1–0) velocity fields show structures possibly associated with discs (elongated velocity gradients) and interacting objects (off-axis velocity components). There is evidence for a decrement in the CO (1–0) surface brightness at the location of the host galaxy, which may indicate radiative feedback from the AGN, or offset star formation. We find CO–H2 conversion factors of around αCO = 1.5 ± 0.5 (K km s−1 pc2)−1, molecular gas masses of >3 × 1010 M⊙, dynamical masses of ∼1011 M⊙, and gas fractions of around 60 per cent. The intrinsic CO line luminosities are comparable to those of unobscured AGN and dusty star-forming galaxies at similar redshifts, but the infrared luminosities are lower, suggesting that the targets are less efficient at forming stars. Therefore, they may belong to the AGN feedback phase predicted by galaxy formation models, because they are not efficiently forming stars considering their large amount of molecular gas

Tectonic model for development of the Byrd Glacier discontinuity and surrounding regions of the Transantarctic Mountains during Neoproterozoic-Early Paleozoic

The Byrd Glacier discontinuity us a major boundary crossing the Ross Orogen, with crystalline rocks to the north and primarily sedimentary rocks to the south. Most models for the tectonic development of the Ross Orogen in the central Transantarctic Mountains consits of two-dimensional transects across the belt, but do not adress the major longitudinal contrast at Byrd Glacier. This paper presents a tectonic model centering on the Byrd Glacier discontinuity. Rifting in the Neoproterozoic producede a crustal promontory in the craton margin to the north of Byrd Glacier. Oblique convergence of the terrane (Beardmore microcontinent) during the latest Neroproterozoic and Early Cambrian was accompanied by subduction along the craton margin of East Antarctica. New data presented herein in the support of this hypothesis are U-Pb dates of 545.7 ± 6.8 Ma and 531.0 ± 7.5 Ma on plutonic rocks from the Britannia Range, subduction stepped out, and Byrd Glacier. After docking of the terrane, subduction stepped out, and Byrd Group was deposited during the Atdabanian-Botomian across the inner margin of the terrane. Beginning in the upper Botomian, reactivation of the sutured boundaries of the terrane resulted in an outpouring of clastic sediment and folding and faulting of the Byrd Group